Scientists develop first-ever application to detect cancer within a single cell

By Kelly Hodgkins Published April 20, 2016

MD Anderson Cancer Center — Facebook

Researchers from the University of Texas MD Anderson Cancer Center have developed the world’s first application capable of detecting cancerous changes in a single cell. This new approach makes it possible for researchers to detect slight alterations in a DNA sequence from multiple individual cells, a level of detection not currently possible using methods that require the analysis of a vast number of cells.

This new method is based on a recent form of DNA analysis called single-cell sequencing (SCS) that looks for DNA mutations in multiple individual cells, allowing researcher to detect cancerous mutations within a tissue sample. This SCS technology differs significantly from the existing next-generation sequencing (NGS) method that measures genomes derived from millions of cells. SCS has made a significant impact in the field of medicine and molecular biology, but the computational tools that analyze the DNA sequences are not as accurate as researchers wanted.

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The University of Texas research team has improved these analytics tools, creating a new application they call Monovar. This method makes it possible to detect small changes in DNA known as single-nucleotide variants (SNVs). SNVs are commonly used as markers to identify both inheritable diseases and DNA-related diseases such as cancer.

Monovar is a flexible tool, capable of analyzing DNA in a variety of applications beyond early cancer detection and treatment. “Monovar will have significant translational applications in cancer diagnosis and treatment, personalized medicine, and prenatal genetic diagnosis, where the accurate detection of SNVs is critical for patient care,” said study co-authors Nicholas Navin, Ph.D., and Ken Chen, Ph.D.. The results of this study were published recently in the online version of Nature Methods.

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Kelly's been writing online for ten years, working at Gizmodo, TUAW, and BGR among others. Living near the White Mountains of…

Outdoors

Juiced Bikes offers 20% off on all e-bikes amid signs of bankruptcy

Juiced Bikes Scrambler ebike

A “20% off sitewide” banner on top of a company’s website should normally be cause for glee among customers. Except if you’re a fan of that company’s products and its executives remain silent amid mounting signs that said company might be on the brink of bankruptcy.That’s what’s happening with Juiced Bikes, the San Diego-based maker of e-bikes.According to numerous customer reports, Juiced Bikes has completely stopped responding to customer inquiries for some time, while its website is out of stock on all products. There are also numerous testimonies of layoffs at the company.Even more worrying signs are also piling up: The company’s assets, including its existing inventory of products, is appearing as listed for sale on an auction website used by companies that go out of business.In addition, a court case has been filed in New York against parent company Juiced Inc. and Juiced Bike founder Tora Harris, according to Trellis, a state trial court legal research platform.Founded in 2009 by Harris, a U.S. high-jump Olympian, Juiced Bikes was one of the early pioneers of the direct-to-consumer e-bike brands in the U.S. market.The company’s e-bikes developed a loyal fandom through the years. Last year, Digital Trends named the Juiced Bikes Scorpion X2 as the best moped-style e-bike for 2023, citing its versatility, rich feature set, and performance.The company has so far stayed silent amid all the reports. But should its bankruptcy be confirmed, it could legitimately be attributed to the post-pandemic whiplash experienced by the e-bike industry over the past few years. The Covid-19 pandemic had led to a huge spike in demand for e-bikes just as supply chains became heavily constrained. This led to a ramp-up of e-bike production to match the high demand. But when consumer demand dropped after the pandemic, e-bike makers were left with large stock surpluses.The good news is that the downturn phase might soon be over just as the industry is experiencing a wave of mergers and acquisitions, according to a report by Houlihan Lokey.This may mean that even if Juiced Bikes is indeed going under, the brand and its products might find a buyer and show up again on streets and trails.

Cars

Volkswagen plans 8 new affordable EVs by 2027, report says

volkswagen affordable evs 2027 id 2all

Back in the early 1970s, when soaring oil prices stifled consumer demand for gas-powered vehicles, Volkswagen took a bet on a battery system that would power its first-ever electric concept vehicle, the Elektro Bus.
Now that the German automaker is facing a huge slump in sales in Europe and China, it’s again turning to affordable electric vehicles to save the day.Volkswagen brand chief Thomas Schaefer told German media that the company plans to bring eight new affordable EVs to market by 2027."We have to produce our vehicles profitably and put them on the road at affordable prices," he is quoted as saying.
One of the models will be the ID.2all hatchback, the development of which is currently being expedited to 36 months from its previous 50-month schedule. Last year, VW unveiled the ID.2all concept, promising to give it a price tag of under 25,000 euros ($27,000) for its planned release in 2025.VW CEO Larry Blume has also hinted at a sub-$22,000 EV to be released after 2025.It’s unclear which models would reach U.S. shores. Last year, VW America said it planned to release an under-$35,000 EV in the U.S. by 2027.The price of batteries is one of the main hurdles to reduced EV’s production costs and lower sale prices. VW is developing its own unified battery cell in several European plants, as well as one plant in Ontario, Canada.But in order for would-be U.S. buyers to obtain the Inflation Reduction Act's $7,500 tax credit on the purchase of an EV, the vehicle and its components, including the battery, must be produced at least in part domestically.VW already has a plant in Chattanooga, Tennesse, and is planning a new plant in South Carolina. But it’s unclear whether its new unified battery cells would be built or assembled there.

Cars

Nissan launches charging network, gives Ariya access to Tesla SuperChargers

nissan charging ariya superchargers at station

Nissan just launched a charging network that gives owners of its EVs access to 90,000 charging stations on the Electrify America, Shell Recharge, ChargePoint and EVgo networks, all via the MyNissan app.It doesn’t stop there: Later this year, Nissan Ariya vehicles will be getting a North American Charging Standard (NACS) adapter, also known as the Tesla plug. And in 2025, Nissan will be offering electric vehicles (EVs) with a NACS port, giving access to Tesla’s SuperCharger network in the U.S. and Canada.Starting in November, Nissan EV drivers can use their MyNissan app to find charging stations, see charger availability in real time, and pay for charging with a payment method set up in the app.The Nissan Leaf, however, won’t have access to the functionality since the EV’s charging connector is not compatible. Leaf owners can still find charging stations through the NissanConnectEV and Services app.Meanwhile, the Nissan Ariya, and most EVs sold in the U.S., have a Combined Charging System Combo 1 (CCS1) port, which allows access to the Tesla SuperCharger network via an adapter.Nissan is joining the ever-growing list of automakers to adopt NACS. With adapters, EVs made by General Motors, Ford, Rivian, Honda and Volvo can already access the SuperCharger network. Kia, Hyundai, Toyota, BMW, Volkswagen, and Jaguar have also signed agreements to allow access in 2025.
Nissan has not revealed whether the adapter for the Ariya will be free or come at a cost. Some companies, such as Ford, Rivian and Kia, have provided adapters for free.
With its new Nissan Energy Charge Network and access to NACS, Nissan is pretty much covering all the bases for its EV drivers in need of charging up. ChargePoint has the largest EV charging network in the U.S., with over 38,500 stations and 70,000 charging ports at the end of July. Tesla's charging network is the second largest, though not all of its charging stations are part of the SuperCharger network.